Sinetrol® - Fat loss for the long-term

Sinetrol® is a natural combination of citrus polyphenols designed to promote healthy fat metabolism and body composition. Sinetrol® is proven to support lipolysis, thermogenesis, and energy expenditure, contributing to reductions in fat mass and improvements in body composition over time. Supported with published clinical trials on Asian and Caucasian subjects. 630 mg/day.

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Sinetrol® - Key features

  • Polyphenol‑rich citrus composition

  • Supports fat burning via lipolysis and thermogenesis

  • Increases resting energy expenditure

  • Shown to reduce fat mass while preserving lean mass

  • Sustained benefits observed after supplementation

Science supporting Sinetrol®

More than 10 years of research have been conducted to characterise Sinetrol®, including its composition, mechanism of action, and effects on body composition. This botanical ingredient has been evaluated in human interventional studies involving over 300 subjects, using robust clinical methodologies with follow‑up assessments.

Characterisation

Primary active compounds
  Naringin
  Hesperidin
  both expressed as flavanones   >40%

Secondary active compounds
  Other flavanones
  Caffeine                                   3.5%

Composition: Grapefruit extracts (Citrus grandis (L.) Osbeck, Citrus paradisi Macfad), Orange extract and juice concentrate (Citrus sinensis (L.) Osbeck) and Guarana extract (Paullinia cupana Kunth).

Recommended daily dosage: Sinetrol® Xpur C - 630 mg

Clinically supported benefits

Double-blind, randomised, placebo-controlled studies on both Caucasian and Asian populations.

LOCATIONS Murcia, Spain
Clinical facility, UCAM		 Seoul, South Korea
Kangbuk Samsung Hospital
YEAR & DURATION 2017
20 weeks (16+4)

2019
12 weeks
POPULATIONS

77 subjects
Caucasian population
BMI: 25-40 kg/m2
Age: 29-52 years old

 86 subjects
Asian population
BMI: 24-30 kg/m2
Age: 25-62 years old
PROTOCOLS

Body composition
DXA scan

Recommended individualised
normo-caloric diet
(Harris and Benedict)

Body composition
DXA scan

Recommended
hypo-caloric diet
(-500 kcal hypocaloric diet)
INTAKES CAPSULES
2 x 450 mg/day		 TABLETS
1 x 900 mg/day

Primary outcome: reduction in body fat mass over 16 weeks

  • 5% total body fat mass loss reported
  • 100% of body weight loss attributable to fat mass
  • 65% of total body fat loss originating from abdominal fat
  • Maintenance of lean mass and increase in lean‑to‑fat mass ratio (+8.1%)
  • Reductions in waist and hip circumference
  • Consistent outcomes reported in Asian and Caucasian populations

Sustainable weight loss

             

Body fat mass reduction observed at the end of supplementation was maintained after a 4‑week follow‑up period without supplementation.

Interactions between Sinetrol® polyphenols and gut-microbiota – new mechanistic data  

An open-label clinical study conducted on 19 subjects explored the role of gut microbiota in the metabolic transformation of the polyphenols contained in Sinetrol®.
- The metabolism of naringenin and hesperidin is microbiota‑dependent, highlighting the role of microbial biotransformation.
- Interactions between gut microbiota and Sinetrol® polyphenols were associated with changes in selected metabolic markers.
- Changes in short‑chain fatty acid (SCFA)–producing microbial populations were observed, with inverse associations between SCFA producers and visceral adipose tissue.

Sinetrol® is safe

No adverse event linked to Sinetrol® supplementation over the period 2008-2023 has been recorded.

Certifications & Compliance

Non-GMO, Halal, gluten-free, suitable for vegetarians and vegans

Approved by MFDS (Korean FDA): may help to reduce body fat

References

CLINICAL TRIALS
Dallas et al. 2008; Phytomedicine
Dallas et al. 2013; Phytother. Res.
Cases et al. 2015; Int. J. Food Sci. Nutr.
Park et al. 2020; J. Med Food
Muralidharan et al. 2024; Nutr Metab 
Muralidharan et al. 2025; Int. J. Food Sci. Nutr.


MECHANISTIC STUDIES
Yoo et al. 2016; J. Korean Soc. Food Sci. Nutr
Lee et al. 2017; J. Korean Soc. Food Sci. Nutr.

BIOAVAILABILITY & NUTRIKINETIC
Muralidharan J. et al. 2023; Food Funct.

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This website is intended to provide information about Biotexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.