Promunel® - Immune & respiratory health
Promunel® is a brown propolis extract obtained through the patented Multi Dynamic Extraction (M.E.D.™) process, ensuring a characterised and standardised polyphenolic profile. Promunel® is designed to support immune function and upper respiratory tract comfort, with its benefits investigated in human clinical studies.
Promunel® – Key Features
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Brown propolis extract obtained via the patented M.E.D.™ process
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Standardised extract ensuring consistent polyphenolic composition
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Supports normal innate immune function
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Helps maintain immune readiness during seasonal challenges
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Contributes to comfort of the upper respiratory tract
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Associated with fewer and shorter episodes of respiratory discomfort in human studies
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Suitable for local application to support upper respiratory tract comfort
Science supporting Promunel®
It has taken many years to develop Promunel®, transforming raw propolis into an advanced ingredient. Traditionally propolis has a complex composition and natural variability but this research has enabled us to produce a characterised and standardised propolis extract. The mechanism of action and benefits of Promunel® have been demonstrated in a study of 122 subjects experiencing upper respiratory tract discomfort.
Process & characterisation
More than 300 polyphenols have been identified in propolis and its bioactive composition is also highly variable depending on geographic area, climatic conditions, plant species and seasonality.
Over the past decade, we have developed the Multi Dynamic Extraction (M.E.D.TM) process to extract a wide polyphenolic spectrum and obtain a wide reproducible fingerprint of characteristic polyphenols.
The M.E.D.TM process used to produce Promunel® allows the extraction of the complete, intact and identified polyphenolic complex. It ensures that at least 25% of the polyphenols in Promunel® are represented by the six main flavonoids of propolis: Galangin, Quercetin, Pinocembrin, Pinobanksin, Apigenin, Chrysin.
Six main flavonoids of propolis in Promunel®
Galangin, Quercetin, Pinocembrin, Pinobanksin, Apigenin, Chrysin
≥25% of the total polyphenols content in HPLC-ESI-MS
To enable application in a range of delivery systems, Promunel® is available in four different formats, each with the same the HPLC-UV profile, guaranteeing the bioactive polyphenols in all of them.
| COMMERCIAL NAME |
ESIT® |
GREIT®
|
EPE® Hydroalcoholic extract |
POLE®
|
| GRADE |
ESIT 12 |
GREIT 120
|
EPE 38 80 GA 38 mg/ml total polyphenols expressed as Galangin UV Folin Ciocaleu HPLC-ESI-MS |
POLE G
|
| RECOMMENDED DAILY DOSE | 100-200 mg | 1-2 ml | 0.31-0.62 ml | 0.4-0.8 ml |
| DELIVERY SYSTEMS | Tablets Capsules |
Spray |
Tinctures | Soft gels Gummies |
Clinically supported benefits
Double-blind, randomised, placebo-controlled study.
| LOCATIONS | Murcia, Spain UCAM, University of Murcia |
| YEAR & DURATION | 2022-2024 12 weeks of supplementation Automn to Spring period |
| POPULATION | 295 subjects Age: 25-69 years old BMI: 18.5-29.9 kg/m2 |
| PROTOCOLS | Upper respiratory tract infections Risk, incidence, occurrence Wisconsin Upper Respiratory Symptom Survey (WURSS24) completed daily on an app |
| INTAKES | CAPSULES 2 x 200 mg / day (one at breakfast and one at dinner) 48 mg of polyphenols |
Reduced incidence of upper respiratory discomfort
Promunel® supplementation was associated with a lower number of upper respiratory discomfort events compared with placebo. This observation reflects a reduction in the overall incidence of discomfort episodes during the supplementation period.
Lower probability of experiencing upper respiratory discomforts and shorter duration of episodes
Clinical observations showed that Promunel® supplementation was associated with a 31% lower probability of experiencing upper respiratory discomforts compared with placebo during the seasonal challenge period.
Promunel® supplementation contributed to a reduction in the average number of days participants experienced upper respiratory discomforts. These findings suggest support for a faster return to normal upper respiratory comfort compared with placebo.
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Double-blind, randomised, placebo-controlled study.
| LOCATIONS | Benevento, Italy Samnium Medical Cooperative |
| YEAR & DURATION | 2020 5 days of supplementation and follow-up T0=baseline; T1=after 3 days; T2=after 5 days Follow-up: T3-15 days after the end of supplementation |
| POPULATION | 122 subjects Age: 18-77 years old Inclusion with mild upper respiratory tract discomfort |
| PROTOCOLS | Clinical evaluation by medical doctor for upper respiratory tract discomfort Throat swabs for bacterial collection Questionnaires |
| INTAKES | Propolis oral spray 2-4 sprays three times/day over 5 days Equivalent to 12-14 mg of standardised polyphenols per day |
Improvement of upper respiratory tract comfort within 3 days of supplementation.
Improvement in upper respiratory tract comfort observed within 3 days of Promunel® oral spray supplementation
- After 3 days, 83% of subjects reported improved upper respiratory tract comfort, compared with 28% in the placebo group
- Lower proportion of subjects reporting sore throat, hoarseness, and local swelling or redness versus placebo
- Mild upper respiratory tract discomfort resolved up to two days earlier in the supplemented group
Promunel® is safe
No adverse event linked to Promunel® supplementation has been recorded.
Certifications & Compliance
Non-GMO, Halal, Kosher, gluten-free, suitable for vegetarians
Available as organic
References
PROCESS
Zaccaria et. al. Materials, 2019
MECHANISTIC STUDIES
Zaccaria et. al. Nutrients, 2017
Garzarella et al. Biomedecine & Pharmacotherapy, 2022
CLINICAL TRIALS
Esposito et al. Phytomedicine, 2020
This website is intended to provide information about Biotexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.
