DNF-10® - Peptides for appetite control
DNF‑10® is a patented, peptide‑rich hydrolysate derived from Saccharomyces cerevisiae, developed to support appetite control and healthy body composition. Through peptide‑derived signalling involved in gut–brain satiety pathways, DNF‑10® helps support satiety signalling and energy‑intake regulation, with clinical studies reporting early benefits on body composition, including reductions in fat mass. Supported by 4 published clinical trials. 500 mg/day.
DNF-10® - Key features
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Patented ingredient
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Helps support appetite and satiety signaling
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Supports calorie reduction as early as from 1st week of intake
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Supports healthy weight management
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100% weight loss occurs from fat loss
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Help support GLP-1 and other appetite-related enterohormones
Science supporting DNF-10®
Backed by over a decade of research, DNF-10® is supported by a strong scientific foundation demonstrating its mechanism of action and clinically supported benefits on body composition. Its role in satiety signalling has been extensively explored in vivo using validated animal models. These findings are further reinforced by interventional human clinical trials, confirming reductions in food intake alongside improvements in body composition.
More than 10 articles supporting the mechanism of action and health benefits of DNF-10® have been published.
Process & characterisation
DNF-10® is a protein hydrolysate from Saccharomyces cerevisiae, a yeast species used for thousands of years in baking, fermented food and beverage manufacturing processes.
The manufacturing of DNF-10® involves enzymatic proteolysis and the use of ultrafiltration to select peptides with a molecular weight <10 kDa. The material is then spray-dried to obtain a dried powder.
Active compounds:
Patented yeast protein hydrolysate from Saccharomyces cerevisiae
Strain NBRC (ex. IFO) 2346
Peptide size: <10 kDa
Composition: Peptides from Saccharomyces cerevisiae
Recommended daily dosage: from 500 mg
Clinically supported benefits
Double-blind, randomised, placebo-controlled clinical studies.
| YEAR & DURATION | 2014 10 weeks |
2017 |
| POPULATIONS |
54 subjects |
30 subjects Women BMI> 25 kg/m2 Age: 20-60 years old |
| PROTOCOLS |
Abdominal fat distribution No specific exercise and diet patterns |
Body composition No specific exercise and diet patterns |
| INTAKES | SACHETS 2 x 500 mg/day |
CAPSULES 2 x 250 mg/day |
Satiety enhancer
- Subjects taking DNF-10® supplements decrease their caloric intake significantly after the first weeks of supplementation.
- After 2 months, the daily caloric intake drops by 600 kcal.
- All 3 groups of macronutrients are significantly impacted: subjects reduce the number of calories from lipids, proteins, and carbohydrates.
- After a few weeks of consuming DNF-10®, subjects have a reduced appetite for sweet foods.
Body weight loss
Weight loss is significant after one month of supplementation with DNF-10®. Moreover, 100% of the weight lost is from fat mass, leading to a 6% reduction in the fat mass ratio.
Abdominal fat reduction
The change in body composition is confirmed by computed tomography. The subjects’ total abdominal fat mass is significantly reduced by 5% with DNF-10®. Waist circumference is reduced by 5 cm after supplementation.
DNF-10® is safe
No adverse event linked to DNF-10® supplementation has been recorded.
Certifications & Compliance
Non-GMO, Halal, gluten-free, suitable for vegetarians
FDA‑notified GRAS status (GRN No. 1033)
Stability validated after heat treatment at 160°C/320°F for 30 min
References
CLINICAL TRIALS
Hong K. et al.; Progr. Nutr., 2015, 17:3:262-264
Jung E. et al.; Phytother. Res., 2009, 3(5):619-23
Jung E. et al.; Nutrition; 2014, 30:25-32
Jung E. et al.; Prev. Nutr. Food Sci.; 2017, 22(1):45-49
MECHANISTIC STUDIES
Park Y. et al.; Food Chemistry, 2013
Jung E.Y. et al., Ann. Nutr. Metab. 2012; 61(2):89-94
Jung E.Y. et al.; Journal of Health Science, 2011; 57(6), 532-539
This website is intended to provide information about Biotexia’s ingredients, used in various food/dietary supplement products around the world. It is only intended for business to business and to provide information to food/dietary supplement professionals and is not designed for the general public. Statements used on this website have not been evaluated by competent authority. Products are not intended to diagnose, treat, cure or prevent any disease.
